Scenario: I have a CobraNet audio card. Every time I reboot the PC it's in, I lose the CobraNet settings for the card.
Solution: The most likely cause is that Persistence is set to "off." (Persistence set to off is the default setting for CobraNet chips.) Use ASIControl (or CNDisco) to set Persistence to "on' by right-clicking on the card in the top of ASIControl and selecting "Configure CobraNet." Look for Persistence in the top section of the CobraNet Configuration dialog box, set it to on, and apply the changes.